Homozygosity
From ISOGG Wiki
Homozygosity is a term used in genetics to describe a situation where an individual inherits the same alleles for a particular gene from both parents.
Contents
Blog posts
- Leah Larkin. Gordon An ROH case study, The DNA Geek, 27 July 2018.
- Kitty Cooper. When the DNA says your parents are related. Kitty Cooper's blog, 25 July 2018.
- Brianne Kirkpatrick. Never stop doing the right thing: commentary on a resource for the community affected by incest and consanguinity Watershed DNA, 17 April 2017.
- Brianne Kirkpatrick. "High ROH" in your DNA - what is it and what can you do next? Watershed DNA, 2 February 2017.
- Brianne Kirkpatrick ROH-related blog posts from Watershed DNA
- Rebekah Canada. Compendium: Runs of homozygosity. Haplogroup blog, 1 March 2016.
- Zakaria Ajmal (Zack). Inbreeding. Procrastination blog, 24 January 2011.
- Razib Khan. Homozygosity runs in the family (or not). Gene Expression blog, 17 November 2010.
Scientific papers
- Ringbauer H, Novembre J, Steinrücken M (2021). Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Nature Communications 12, 5425.
- Rehder CW, David KL, Hirsch B et al (2013). American College of Medical Genetics and Genomics: standards and guidelines for documenting suspected consanguinity as an incidental finding of genomic testing. Genetics in Medicine 15: 150-152.
- Pemberton TJ, Absher D, Feldman MW et al (2012). Genomic patterns of homozygosity in worldwide populations. 91 (2): 275-292.
- Kirin M, McQuillan R, Franklin CS et al (2008). Genomic runs of homozygosity record population history and consanguinity. PLOS One Published online 15 November 2010.
- Paul DB, Hamish G Spencer HG. “It's ok, we're not cousins by blood”: the cousin marriage controversy in historical perspective. PLOS Biology, 23 December 2008.
- McQuillan R, Leutenegger A-L, Abdel-Rahman R et al. Runs of homozygosity in European populations. 83 (3): 359-372.
- Woods CG, Cox J, Springel K et al. Quantification of homozygosity in consanguineous individuals with autosomal recessive disease. American Journal of Human Genetics 2006 78(5): 889–896.
Tools
- Search for runs of homozygosity A free utility from David Pike that allows the user to adjust the criteria to search for varying degrees of ROH
- Are your parents related? A free utility from GedMatch which allows the user to search for large ROHs to determine if their parents are related
- Checking for runs of homozygosity. A free script written in R by Rebekah Canada. Haplogroup blog, 1 March 2016.
- Borland Genetics Runs of Homozygosity tool. A free Borland Genetics tool that in addition to identifying ROHs, predicts the relationship ranges of the donor's parents, if any.
See also
This article uses material in the public domain from the Talking Glossary of Genetic Terms and is reproduced courtesy of the National Human Genome Research Institute. |