Linkage disequilibrium
From ISOGG Wiki
Linkage disequilibrium is a term used in population genetics to describe a non-random association of alleles at two or more loci on the same chromosome reflecting haplotypes descended from a single ancestral chromosome.
Scientific papers
- Fox, Emma A, et al. (2019). ngsLD: evaluating linkage disequilibrium using genotype likelihoods. Bioinformatics 35(19): 3855-3856.
- Somers, Metten, et al. (2017). A Genetic Population Isolate in The Netherlands Showing Extensive Haplotype Sharing and Long Regions of Homozygosity. Genes 8(5): 133.
- Charles, Bashira A, et al. (2014). Accounting for Linkage Disequilibrium in Association Analysis of Diverse Populations: Leveraging Linkage Disequilibrium. Genetic Epidemiology 38(3): 265-273.
- Slatkin M (2008). Linkage disequilibrium — understanding the evolutionary past and mapping the medical future. Nature Reviews Genetics 9: 477-485.
- Service, Susan, et al. (2006). Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies (letter). Nature Genetics 38: 556-560. Link to ResearchGate public reprint.
- De la Vega, Franciso M, et al. (2005). The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Research 15(4): 454-462.
- Ke, Xiayi, et al. (2004). The impact of SNP density on fine-scale patterns of linkage disequilibrium. Human Molecular Genetics 13(6): 577-588.
- Reich DE, Cargill M, Bolk S, et al. (2001). Linkage disequilibrium in the human genome (letter). Nature 411: 199-204.