Y-DNA Haplogroup C and its Subclades - 2008
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Version History Last
revision date for this specific page: 17 December 2008
Because of continuing research, the structure of the Y-DNA Haplogroup Tree changes and ISOGG
does its best to keep the tree updated with the latest developments
in the field. The viewer may observe other versions of the tree on the Web. Email
Alice Fairhurst if the differences need
C M130/RPS4Y711, M216, P184, P255, P260
C1 M8, M105, M131, P122
C2a M208 (formerly C2b)
� � �
� � �
C2a1 P33 (formerly C2a)
� � �
C3 M217, P44, PK2
C3c M48, M77, M86
C4 M347, P309
C4a M210 (formerly C4b)
C4b DYS390.1 del
(formerly C4a; not listed in Karafet 2008)
- The DYS390.1 deletion that characterizes haplogroup C4b is not a true SNP.
DYS390 is a complex marker, and the deletion of four repeats from the first
element of the marker is characteristic of the majority of tested M347
- Identical SNPs that were discovered separately are listed in alphabetical order, not necessarily in
the order of discovery, and separated by "/". Example: M130/RPS4Y711.
Y-DNA haplogroup C appears to have arisen shortly after modern humans left Africa and
is estimated to be approximately 50,000 years old. The
haplogroup can be traced across the southern Arabian Peninsula through Pakistan and India
into Sri Lanka and Australia, and Southeast Asia.
C* is found on the Indian subcontinent, Sri Lanka and in parts of SE Asia. The rare C1 lineage
appears to be restricted to Japan. C2 is found predominantly in New Guinea, Melanesia, and
Polynesia. The successful C3 lineage is believed to have originated in southeast or central Asia,
spreading from there into northern Asia and the Americas. C3 is also found in low concentrations
in eastern and central Europe, where it may represent evidence of the westward expansion of the
Huns in the early middle ages; subhaplogroup C3b seems to be found only in the Americas.
C4 is found exclusively among aboriginal Australians and is dominant in that population.
C5 has a significant presence in India with a single instance known from Pakistan.
C6 is a recently recognized group whose geographical associations were not reported.
Bortolini et al,
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas.
American Journal of Human Genetics, 73:524�539, (2003).
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Population Structure in the Mediterranean Basin: A Y Chromosome Perspective. (pdf)
Annals of Human Genetics, 2005.
Cinnioglu et al,
Excavating Y-chromosome Haplotype Strata in Anatolia. (pdf) Human Genetics. 114:127-148, 2004.
Deng et al, Evolution
and Migration History of the Chinese Population Inferred from the Chinese Y-chromosome Evidence.
(pdf) Journal of Human Genetics, 49:339-348, 2004.
Hammer et al,
Dual Origins of the Japanese: Common Ground for Hunter-gatherer and Farmer Y Chromosomes.
(abstract) Journal of Human Genetics, 51:47-58, 2006.
Peopling of Sahul: Evidence from mtDNA and Y-Chromosome.
Thesis (M.SC.) University of Tartu, Estonia, 2006.
Karafet et al,
New Binary Polymorphisms Reshape and Increase Resolution of the Human Y-Chromosomal Haplogroup
Tree. Abstract. Genome Research, published online April 2, 2008.
Karafet et al,
Paternal Population History of East Asia: Sources, Patterns,
and Microevolutionary Processes. (pdf) American Journal of Human Genetics,
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Independent Histories of Human Y Chromosomes from Melanesia and Australia.
American Journal of Human Genetics, 68:173-190, 2001.
Kayser et al,
Melanesian and Asian Origins of Polynesians: mtDNA and Y-Chromosome Gradients across
the Pacific. MBE Advance Access published August 21, 2006.
Kayser et al.
Reduced Y-Chromosome, but Not Mitochondrial DNA, Diversity in Human Populations from West New
Guinea. American Journal of Human Genetics, 72:281-302, 2003.
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The Genetic Heritage of the Earliest Settlers Persists in both Indian Tribal and Caste
Populations. (pdf) American Journal of Human Genetics, 72:313-332, 2003.
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Detection of Novel Y SNPs Provides Further Insights into Y Chromosomal Variation in Pakistan.
Journal of Human Genetics, 2006.
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Mol Biol Evol. 2007 Sep 10; [Epub ahead of print]
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Iran: Tricontinetnal Nexus for Y-Chromosome Driven Migration. (abstract)
Human Heredity, Vol. 61, No 3, 132-143, 2006.
Scheinfeldt et al,
Unexpected NRY Chromosome Variation in Northern Island Melanesia. (Link and comments from
Dienekes' Anthropological Blog) Society for Molecular Biology, 2006.
Sengupta et al,
Polarity and Temporality of High Resolution Y-chromosome Distributions in India
Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence
of Central Asian Pastoralists. (pdf)
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Annual Review Genetics, 41:539-564, December 1, 2007(a).
Ed Martin, C/C3 Haplogroup
Corrections/Additions made since 31 December 2007:
- Added Karafet et al (2008) on 4 May 2008.
- First paragraph of haplogroup description revised 4 May 2008.
- PK2 (formerly in Notes) was placed on tree 4 May 2008.
- New snps on 4 May 2008: P53.1, P54, P55, P62, P92, P121, P122, P184, P255, P260, PK2.
- Added Underhill et al (2007a) on 4 May 2008.
- Changed contact person from David Wilson to Charles Moore on 29 September 2008.
- Added P309 on 17 December 2008.
Contact Person for Haplogroup C: Charles Moore