Y-DNA Haplogroup C and its Subclades - 2013
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Version History Last
revision date for this specific page: 30 November 2013
Because of continuing research, the structure of the Y-DNA Haplogroup Tree changes and ISOGG
does its best to keep the tree updated with the latest developments
in the field. The viewer may observe other versions of the tree on the Web. Email
Alice Fairhurst if the differences need
clarification or if you find any broken links on this page.
C IMS-JST029149, IMS-JST037816-80,
M130/Page51/RPS4Y711, M216, P184, P255/P325,
P260/P324, Page85, V77, V183, V199, V232
�
C* -
�
C1 IMS-JST037816, M8, M105, M131, P122
� �
C1* -
� �
C1a P121
�
C2 M38
� �
C2* -
� �
C2a M208
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�
C2a* -
� �
�
C2a1 P33_1, P33_2, P33_3
� �
�
C2a2 P54
�
C3 M217, P44, Z1453
� �
C3* -
� �
C3a M93
� �
C3b L1373
� �
�
C3b* --
� �
�
C3b1 P39
� �
�
C3b2 M48
� �
� �
C3b2* --
� �
� �
C3b2a M77, M86
� �
C3c P53.1
� �
C3d P62
� �
C3e M546, Z1338/F2613
� �
�
C3e* -
� �
�
C3e1 Z1300
� �
� �
C3e1* -
� �
� �
C3e1a M407
� �
C3f IMS-JST002613-27
�
C4 M347, P309
� �
C4* -
� �
C4a M210
�
C5 M356
� �
C5* -
� �
C5a P92
�
C6 V20, V71, V86, V182,
V184, V219
� �
C6a V222
An Extended Version of C Tree with STR Marker Categories
created by Content Expert Ray Banks.
Experimental C Tree by Ray Banks.
Private SNPs are being removed from the tree and placed in the following category:
Private SNPs - After having been investigated, these SNPs have not met the population distribution
criteria for placement on the tree. Either too few confirmed positive testers have been found OR multiple
confirmed testers were confined to either a single surname or to a small group of related males.
- P55 is downstream of M130. Listed 5 August 2012.
SNPs under Investigation - Additional testing is needed to confirm adequate positive samples
and/or correct placement on the tree.
- PK2 has an uncertain location; the primer in Mohyuddin et al (2006) may be
incorrect. Listed 3 January 2013.
- F3952.1, IMS-JST645622+13 is located at approximately M217. Listed 21 March 2013.
- F3393/Z1426 is located at approximately M216 and negative in M217. Listed 7 May 2013.
- CTS11043 is located downstream of F3393/Z1426 and negative in M38. Listed 7 May 2013.
- F894 and Z4113 are located downstream from M217 and
upstream from F2613/Z1338. Listed 7 May 2013.
- CTS2457.1, CTS3385, F3880 and F4013 are located at
approximately Z1300 and negative in M407. Listed 7 May 2013.
- F1396, F1699 and F1756 are located at approximately M217
and having DYS488=null. Listed 7 May 2013.
- L1367, L1370, L1371 and L1372 are located at approximately
M77. Listed 25 May 2013.
- L1368 and L1369 are located at approximately M48. Listed
25 May 2013.
- F4002 is located downstream from L1373 and negative in P39 and M48 and having DYS388=14.
Listed 3 October 2013.
- CTS6678, CTS10729, CTS11058, Z7054, Z7174 are located downstream from P121 and parallel to Z1356. Listed 29 November 2013.
- Z1356, Z1357, Z7156, Z7159, Z7162 are located downstream from P121 and parallel to CTS6678. Listed 29 November 2013.
- F1067 is located downstream from M217, upstream from Z1338, and parallel to L1373. Listed 29 November 2013.
- M386, M401, M532, M504 are located at approximately L1373. Listed 30 November 2013.
NOTES:
- Identical SNPs that were discovered separately are listed in alphabetical order, not necessarily in
the order of discovery, and separated by "/". Example: M130/RPS4Y711.
Y-DNA haplogroup C is thought to have arisen shortly after modern humans left Africa.
Descendants spread mostly through southern and eastern Asia, but branches developed also in the Americas,
islands south of Malaysia, Australia, central Asia and Europe.
C* is found on the Indian subcontinent, Sri Lanka and in parts of SE Asia. The rare C1-M8 lineage appears to be
restricted to Japan. C2-M38 is found predominantly in New Guinea, Melanesia, and Polynesia. The C3-M217 lineage is most
common of them all and is believed to have originated in southeast or central Asia, spreading from there into
northern Asia and the Americas. C3-M217 is also found in low concentrations in eastern and central Europe, where it
may represent evidence of the westward expansion of the Huns in the early Middle Ages and later the Mongols.
Subhaplogroup P39 seems to be found only in the Americas. Z1338 combines both eastern and central Asian groups.
C4 is found exclusively among aboriginal Australians and is dominant in that population. C5-M356 has a significant
presence in India with a single instance known from Pakistan. C6-V20 is a recently recognized group most common in
Europe, and developing information suggests it may more properly form a subgroup with C1.
Membership in the C-P53.1 subgroup of C3 has become difficult to define because of varied testing results among closely related men.
Using variation in STR markers, Zhong et al. in 2010 estimated the divergence times of some Hg C subgroups as they then existed as follows
(thousands of years):
C1-M8 41.9�16.6
C3*-M217 32.6�14.1
C3b-P39 14.5�5.1
C3c-M48 9.3�3.3
C3d-M407 12.0�4.2
C3e-P53.1 14.4�5.1
C5-M356 33.3�19.1
References:
Behar et al,
Genome-Wide Structure of the Jewish People.
Nature, 446:238-42, 2010.
Bortolini et al,
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas.
American Journal of Human Genetics, 73:524�539, (2003).
Bosch et al,
Paternal and Maternal Lineages in the Balkans Show a Homogeneous Landscape over Linguistis Barriers
except for the Isolated Aromuns.
Annals of Human Genetics, 70:459-87, (2006).
Capelli et al,
Population Structure in the Mediterranean Basin: A Y Chromosome Perspective. (pdf)
Annals of Human Genetics, 2005.
Cadenas et al,
Y-chromosome Diversity Characterizes the Gulf of Oman.
European Journal of Human Genetics, 16:374-386, 2008.
Chen et al,
Y Chromosome Genotyping and Genetic Structure of Zhuang Populations. (abstract)
Acta Genetica Sinica, 33(12), 1060-72, 2006.
Cinnioglu et al,
Excavating Y-chromosome Haplotype Strata in Anatolia. (pdf) Human Genetics. 114:127-148, 2004.
Cristofaro et al,
Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge.
PLoS ONE 8(10): e76748. doi:10.1371/journal.pone.0076748, 2013.
Cruciani et al,
A Revised Root for the Human Y Chromosomal Phylogenetic Tree--The Origin of Patrilineal Diversity in Africa.
The American Journal of Human Genetics, doi:10.1016/j.ajhg.2011.05.002, 2011.
Delfin et al,
The Y Chromosome Landscape of the Philippines: Extensive Heterogeneity and Varying Genetic Affinities of
Negrito and Non-Negrito Groups. (abstract)
European Journal of Human Genetics, 19:224-30, 2011.
Derenko et al,
Contrasting patterns of Y-Chromosome variation in South Siberian populations from Baikal
and Altai-Sayan regions, Human Genetics 118: 591-604, 2006.
Dulik et al,
Mitochondrial DNA and Y Chromosome Variation Provides Evidence for a Recent Common Ancestry between Native
Americans and Indigenous Altaians. (pdf) The American Journal of Human Genetics, doi:
10.1016/ajhg.2011.12.014, 2012.
Dulik et al,
Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the
Influence of Mongolian Expansions. (pdf)
PLoS ONE, Vol. 6, Issue 3, e17548, 2011.
Eaaswarkhanth et al,
Traces of Sub-Saharan and Middle Eastern Lineages in Indian Muslim Populations.
European Journal of Human Genetics, 18, 354-363, 2010.
Fornarino et al,
Mitochondrial and Y-chromosome Diversity of the Tharus (Nepal): A Reservoir of Genetic Variation.
BMC Evol Biol. 2009; 9: 154. Published online 2009 July 2. doi: 10.1186/1471-2148-9-154, 2009.
Gayden et al,
The Himalayas as a Directional Barrier to Gene Flow.
American Journal of Human Genetics, 80(5):884-894, 2007.
Geppert et al,
Hierarchical Y-SNP Assay to Study the Hidden Diversity and Phylogenetic Relationship of Native Populations in South America,
Forensic Science International: Genetics, 6 Oct 2010. [Epub ahead of print]
Hammer et al,
Dual Origins of the Japanese: Common Ground for Hunter-gatherer and Farmer Y Chromosomes.
(abstract) Journal of Human Genetics, 51:47-58, 2006.
Hudajashov et al,
Revealing the Prehistoric Settlement of Australia by Y chromosome and mtDNA Analysis.
PNAS, 104:21, 2007.
Jin et al,
Genetic Diversity of Two Haploid Markers in the Udegey Population from Southeastern Siberia. (abstract)
American Journal of Physical Anthropology, 142:303-313, 2010.
Jin et al,
The Peopling of Korea Revealed by Analyses of Mitochondrial DNA and Y-Chromosomal Markers.
PLoS One, vol 4(1):ed4210, 2009.
Karafet et al,
Major East-West Division Underlies Y Chromosome Stratification Across Indonesia. Abstract.
Molecular Biology and Evolution, doi:10.1093/molbev/msq063. 2010.
Karafet et al,
New Binary Polymorphisms Reshape and Increase Resolution of the Human Y-Chromosomal Haplogroup
Tree. Abstract. Genome Research, published online April 2, 2008.
Supplementary Material.
Kayser et al,
Independent Histories of Human Y Chromosomes from Melanesia and Australia.
American Journal of Human Genetics, 68:173-190, 2001.
Kayser et al,
The Impact of the Austronesian Expansion: Evidence from mtDNa and Y Chromosome Diversity
in the Admiralty Islands of Melanesia.
Molecular Biology Evolution, 25(7):1362-1374, 2008.
Kayser et al,
Melanesian and Asian Origins of Polynesians: mtDNA and Y-Chromosome Gradients across
the Pacific. MBE Advance Access published August 21, 2006.
Li et al,
Paternal Genetic Affinity between Western Austronesians and Daic Populations
BMC Evolutionary Biology, Vo. 15(8), p. 146, 2008.
Malhi et al,
Distribution of Y Chromosomes among Native North Americans: A Study of Athapaskan Population History
American Journal of Physical Anthropology, 137:412-24, 2008.
Malyarchuk et al,
On the Y-chromosome Haplogroup C3c Classification.
Abstract. Journal of Human Genetics. Epub ahead of print, 2012 Jul 19.
Malyarchuk et al,
Phylogeography of the Y-Chromosome Haplogroup C in Northern Eurasia. (abstract)
Annals of Human Genetics, 74:539-46, 2010.
Mohyuddin et al,
Detection of Novel Y SNPs Provides Further Insights into Y Chromosomal Variation in Pakistan.
Journal of Human Genetics, 2006.
Mona et al,
Patterns of Y-chromosome Diversity Intersect with the Trans-New Guinea Hypothesis.
Mol Biol Evol. 2007 Sep 10; [Epub ahead of print]
Naitoh S, et al,
Assignment of Y-chromosomal SNPs Found in Japanese Population to Y-chromosomal Haplogroup tree.
Journal of Human Genetics, 2013 Feb 7. doi: 10.1038/jhg.2012.159, 2013.
Nonaka et al,
Y Chromosomal Binary Haplogroups in the Japanese Population and their Relationship to 16 Y-STR Polymorphisms. (abstract)
Annals of Human Genetics, 71:480-495, 2007.
Pakendorf et al,
Investigating the Effects of Prehistoric Migrations in Siberia: Genetic Variation and the Origins of Yakuts,
Human Genetics, Volume 120, Number 3, 334-353, 2006.
Scheinfeldt et al,
Unexpected NRY Chromosome Variation in Northern Island Melanesia.
Society for Molecular Biology, 2006.
Sengupta et al,
Polarity and Temporality of High Resolution Y-chromosome Distributions in India
Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence
of Central Asian Pastoralists. (pdf)
American Journal of Human Genetics, 78:202-221, 2006.
Sharma et al,
The Indian Origin of Paternal Haplogroup R1a1 Substantiates the Autochthonous Origin of Brahmins and the Caste
SystemOrigin of Paternal Haplogroup R1a1. (abstract)
Journal of Human Genetics, 54:47-55, 2009.
Shou et al,
Y-Chromosome Distributions among Populations in Northwest China Identify Significant Contribution from
Central Asian Pastoralists and Lesser Influence of Western Eurasians. (abstract)
Journal of Human Genetics, 55: 314-22, 2010.
Underhill et al,
Use of Y Chromosome and Mitochondrial DNA Population Structure in Tracing Human Migrations. (abstract)
Annual Review Genetics, 41:539-564, December 1, 2007(a).
Underhill et al,
Y Chromosome Sequence Variation and the History of Human Populations. (pdf) Nature Genetics, 26:
358-361, November 2000.
Xue et al,
A Spatial Analysis of Genetic Structure of Human Populations in China Reveals Distinct Difference between
Maternal and Paternal Lineages.
European Journal of Human Genetics, 16:705-17, 2008.
Zhao et al,
Presence of Three Different Paternal Lineages among North Indians: A Study of 560 Y Chromosomes. (abstract)
Annals of Human Biology, 36(1):46-59, 2009.
Zhong et al,
Extended Y-chromosome Investigation Suggests Post-Glacial Migrations of Modern Humans into East Asia via the
Northern Route.
Molecular Biology, 28(1):717-727, 2011.
Zhong et al,
Global Distribution of Y-Chromosome Haplogroup C Reveals the Prehistoric Migration Routes of African Exodus
and Early Settlement in East Asia. (abstract)
Journal of Human Genetics, 55(7):428-35, 2010.
Additional Resources:
ISOGG Wiki - What you need to know about Genetic Genealogy.
C Haplogroup, Ed Martin, Ray Banks.
Haplogroup C Project, Ray Banks.
Corrections/Additions made since 1 January 2013:
- Moved V20 from Investigation to tree; added V71, V86, V182, V184, V219, V222 to tree; added V77, V183, V199,
V232 to Investigation on 3 January 2013.
- Moved PK2 from tree to Investigation; added Cruciani et al (2011) on 3 January 2013.
- Added F2613 on 9 January 2013.
- Added Naitoh et al (2013) on 21 March 2013.
- Added IMS-JST002613-27, IMS-JST029149, IMS-JST037816, IMS-JST37816-80 to tree;
added F3952.1, IMS-JST645622+13 to Investigation on 21 March 2013.
- Added Experimental C Tree by Ray Banks on 7 May 2013.
- Added CTS2457.1, CTS3385, CTS11043, F894, F1396, F1699, F1756, F3393/Z1426, F3880, F4013, Z4113 to Investigation
on 7 May 2013.
- Added L1367, L1368, L1369, L1370, L1371, L1372, L1373 to Investigation on 25 May 2013.
- Moved L1373 from Investigation to tree on 10 August 2013.
- Modified haplogroup description for Haplogroup C on 1 September 2013.
- Moved V77, V183, V199, V232 from Investigation to tree; added F4002 to Investigation on on 3 October 2013.
- Added CTS6678, CTS10729, CTS11058, F1067, Z1356, Z1357, Z7054, Z7174, Z7156, Z7159, Z7162 to Investigation on 29 November 2013.
- Added M546 to tree; added M386, M401, M532, M504 to Investigation; added Cristofaro et al (2013) on 30 November 2013.
Contact Person for Haplogroup C: Ray H. Banks