Autosomal DNA tools
From ISOGG Wiki
Note that this list is provided for information only. Inclusion on this list does not imply recommendation or endorsement by ISOGG.
Using DNA match results
- 529andYou A Google Chrome extension for use with data from 23andMe. For details see the reviews by Kitty Cooper and Rebecca Walker
- AncestryDNA Helper A Google Chrome extension provided by Jeff Snavely which allows you to extract and download a spreadsheet of your matches.
- Autosomal DNA utility A free tool provided by Wesley Erickson. It allows the user to compare multiple matches at 23andMe or Family Tree DNA in a single chromosome browser.
- DNAGedcom This site was created by Rob Warthen to help users quickly analyze their data. This site and related tools allows you to download data from FTDNA, Ancestry and 23andMe. In addition, it has the ability to compare many Gedcoms at one time through the GWorks utility. The Autosomal DNA Segment Analysizer provides a visual representation of your Family Finder matches and the overlapping segments. Additional tools are available for a small fee from the DNA Gedcom Client which allows the user to download a list of AncestryDNA matches with centiMorgan data and pedigrees. The information from here can then be uploaded to DNAGedcom and your matches Ancestors are then compared through the GWorks utility.
- DNA Genealogy Experiment A selection of experimental tools for visualising DNA matches including the Family Finder segment triangulator.
- DNA Painter A free website created by Jonny Perl which allows the user map DNA segments and identify patterns in the data. For details see the video tutorial from Blaine Bettinger.
- DNA Painter Shared cMs tool
- Double Match Triangulator A free program provided by Louis Kessler
- GEDmatch A free utility to compare autosomal DNA data files from all three testing companies and to compare Gedcom files. A number of other very useful tools are also provided, some for a fee.
- Genome Mate A tool for comparing autosomal DNA data and identifying common ancestors developed by Becky Walker, a 23andMe member and a programmer.
- MedBetterDNA A Chrome extension which enhances the AncestryDNA match system. It puts the notes on the match which is a big timesaver.
- NodeXL A free Excel template which can be used to visualise AncestryDNA matches. See the detailed tutorial from Shelley Crawford
- Overlapping segments viewer A tool provided by Staffan Betnér for comparing all matching segments for all matches based on Family Finder data.
- Relationship Estimator App A free utility provided by the DNA Adoption team.
Using raw DNA data
- David Pike's Tools Utilities for analysing raw DNA data
- DNA Fit. A commercial company which accepts uploads of 23andMe data and will provide a report for a fee on diet, fitness, sports and wellbeing.
- Codegen. A free comprehensive health report using 23andMe raw data.
- DNA.Land A not-for-profit community website run by academics affiliated with Columbia University and the New York Genome Center. The site offers a biogeographical analysis, imputation and a relative-matching feature.
- Gene Heritage. A service using raw DNA data to compile reports about how genes have been passed down in a family. Reports on the ancestral origin of these genes as well as on how they influence traits.
- GeneKnot A site which allows the user to upload genome data and compare DNA with other people with similar disease risks
- Golden Helix Genome Browser For details see Analyze your 23andMe genotype files with Golden Helix by Gabe Rudy, @gabeinformatics blog, 22 July 2015.
- Imputeme A service that imputes 23andme/ancestry/myheritage data to provide extra SNPs as well as multi-SNP risk-signatures for all common disease traits, and extra rare-mutation investigations.
- Infinome - a citizen science project that features a comprehensive interpretation engine for 23andMe data
- Interpretome A set of online tools from Stanford University for analysing your personal genomic data. For further explanation see this blog post by Daniel MacArthur.
- lineage A tool provided by Andrew Riha for analysing raw data files. There are options to merge raw data files from different DNA testing companies, compute centiMorgans of shared DNA between individuals using HapMap tables, plot shared DNA between individuals, determine genes shared between individuals, find discordant SNPs between child and parent(s), and remap SNPs between assemblies / builds (e.g., convert SNPs from build 36 to build 37, etc.).
- Livewello Provides health and trait reports using raw data from 23andMe, AncestryDNA and FTDNA for physicians and advanced users. Twenty reports are provided free of charge with the Livewello Gene App. A subscription is required to access the manually curated health reports. The website also offers free health record managers and data charting applications.
- NCBI Genome remapping service
- OpenSNP OpenSNP allows customers of direct-to-customer genetic tests to publish their test results, find others with similar genetic variations, learn more about their results, find the latest primary literature on their variations and help scientists to find new associations.
- Oxford Statistics Phasing Server A free utility to phase whole genomes based on VCF files
- Promethease Accepts data from any genetic genealogy company and will generate health and trait reports based on current literature.
- Reich Lab software A range of tools is available from the Reich Lab. These programmes are likely to be of interest to advanced users.
- Wegene.com A Chinese company which provides an analysis of 23andMe results.
Using manually input data
- Autosomal (atDNA) Relationship Prediction Utility free by Gliesian, LLC.
- Geography of Genetic Variants Browser See the preprint Visualising the geography of genetic variants by Joseph Marcus and John November for a detailed explanation.
- Segment Calculator A spreadsheet provided by Brian Densmore which allows the user to calculate the odds of a segment being shared by cousins in families of different sizes.
Using whole genome data
- Extracting a 23andMe V3 file from a whole genome BAM file Thomas Krahn has developed a script to generate a 23andMe file from a whole genome sequence to allow the user to upload the file to GEDMatch and other third-party tools.
- Whole genome data can be submitted to Promethease.
Using GEDCOM files
- DNAGedcom A free utility to compare Ancestry Match files, FTDNA Trees and other Gedcoms for common ancestors. The tool is called GWorks on the DNAGedcom web site.
- GEDmatch A free utility to compare autosomal DNA data files from all three testing companies and to compare Gedcom files. A number of other very useful free tools are also provided. Additional tools available for a small fee.
- Learnforever Learn B F Lyons' Exploring Family Trees site allows a user to upload a GEDCOM file to produce a visualisation of pedigree collapse. For further details see the review article The “Exploring Family Trees” Tool by Leah Larkin (The DNA Geek blog, 3 January 2016).
- DIY Genomics
- DIY Genomics on AppBrain
- DNA Match for the iPAD An iPad app for the processing of autosomal DNA data which serves as an alternative to the use of conventional spreadsheets. See also the DNA Match YouTube channel
- MorganSense Predictions Calculator free by Gliesian, LLC.
- HungryBot - provides 23andMe genetic interpretation as well as meal logging for obesity research
- GeneKnot An experimental community where you can compare your disease risk with other users.
- DIY Genomics
No longer available/supported/maintained
- 23++ ("Customers tested in 2014 or later are on the new site and cannot benefit from the extension") A Google Chrome extension for use with data from 23andMe. For details see the 23++ Blog (domain no longer exists)
- Athletigen (Tool no longer available to individuals, only a waitlist) A tool using 23andMe which gives you a report on athletic performance
- FTDNA Ged to GEDCOM converter This site is no longer available with the change to FTDNA format. DNAGedcom will be providing an updated tool for this feature.
- GedMatch Plus (Chrome extension no longer exists) A free Google Chrome browser extension provided by Felix Immanuel which automatically caches your one-to-many, one-to-one, and X one-to-many analyses for seven days and helps to reduce the load on the servers.
- Genes and Us (domain no longer exists) A free service which allows users to upload their 23andMe data to see which genes and traits they are likely to pass on to their children.
- Genetic genealogy tools ("ceased developing Genetic Genealogy Tools") A selection of genetic genealogy tools provided by Felix Immanuel in Adelaide, South Australia. The tools include a Build 36 to 37 converter for autosomal raw data files and a 23andMe genes converter.
- Ian Logan's minor allele program. (broken link) A program which identifies rare and uncommon SNPs. The program is designed to work with the v3 Illumina chip used by 23andMe and Family Tree DNA's Family Finder test.
- What else can I do with my DNA results by Blaine Bettinger, The Genetic Genealogist, 22 September 2013.
- Wang C, Cahill TJ, Parlato A et al (2017). Consumer use and response to online third-party raw DNA interpretation services. Molecular Genetics and Genomic Medicine. Published online 2 November 2017.
- Badalato L, Kalokairinou L and Borry P (2017). Third party interpretation of raw genetic data: an ethical exploration. European Journal of Human Genetics advance online publication 23 August 2017.